Intracranial blister aneurysms (BAs) are challenging vascular lesions related to high morbidity and mortality rates. Different surgical and endovascular techniques have been proposed to treat BAs; however, there is no consensus on a preferred treatment.
To systematically review the pertinent literature on clinical and radiological outcomes of different surgical treatments for BAs management, to meta-analyze their clinical and radiological outcomes, and compare these results with those from recent meta-analyses on endovascular treatments for BAs.
The present study was consistently conducted according to the PRISMA guidelines. Five different online medical databases (PubMed, Medline, EMBASE, Scopus, and Web-of-Science) were screened from 2010 through 2020. Papers reporting clinical and radiological outcomes of different surgical treatments for BAs were considered. Event rates were pooled across studies using random-effects meta-analysis.
A total of 35 studies reporting on 514 patients (534 aneurysms) were included. Aneurysm clipping in 223 patients (45.4%; 95% CI 21.9-53.8), bypass and trapping in 87 (17.7%; 95% CI 1.89-21.6), clipping and wrapping in 82 (16.7%; 95% CI 3.71-19.0), and wrapping in 33 (6.7%; 95% CI 0.0-4.87) were the mostly common performed treatments. Complete occlusion rate was reported in 90.7% of patients. The complication rate was as high as 61.1%, the mortality rate was 7.4%, and the mean mRS at follow-up was 2.5.
Our meta-analysis suggests that surgical treatments for BAs are related to higher occlusion, complications and mortality rate than endovascular strategies. However, there is a high-heterogeneity among the included studies and data are poorly reported; so comparing the two type of treatments is unreliable in order to establish which one is better.

Surgical treatment of intracranial blister aneurysms: A systematic review.

A number of clinical studies have highlighted the success of antibiotics formulated at concentrations between 0 and 6% w/w into bone cements to address localized infections. Separately, some commercial manufacturers have produced gentamycin-infused bone cement mixtures as a countermeasure to infection. The anecdotal evidence suggests that antibiotic infused cements can help eradicate or delay the onset of infections. Quantifying the functionality of that response is more challenging. We have surveyed the literature to identify studies in which controlled drug release or mechanical behavioral assessments have been conducted on drug-infused cements. The focus here is on vancomycin (VAN) in part due to its higher potency relative to gentamycin and its more common usage for staph infections. Takeaways from the limited pool of research studies indicate that large fractions (>99%) of the infused vancomycin remain sequestered in the cement and aren't bioavailable after solidification. Antibiotic fluence ranged from 1 to 283 μg/cm

A meta-analysis of bone cement mediated antibiotic release: Overkill, but a viable approach to eradicate osteomyelitis and other infections tied to open procedures.

Several epidemiological studies have found an association between shoulder-loaded work activities and specific shoulder diseases. No study has derived the dose-response relationship and resulting doubling dose, important for the recognition of occupational diseases. This systematic review is an update of the van der Molen et al. (2017) review. Based on its methodologies, we identified new studies published up to November 2018. The dose-response relationship between physical occupational demands (hands at/above shoulder level, repetitive movements, forceful work, hand-arm vibrations) and specific shoulder diseases (defined as ICD-10 M 75.1-5: rotator cuff syndrome, bicipital tendinitis, calcific tendinitis, impingement, and bursitis) was derived. No evidence for sex-specific differences in the dose-response relationship was found. If there were at least two studies with comparable exposures, a meta-analysis was carried out. The pooled analysis resulted in a 21% risk increase (95% CI 4-41%) per 1000 h of work with hands above shoulder level. A meta-analysis was not possible for other occupational burdens due to the low number of studies and differing exposure measurements; an estimate of the doubling dose was made based on the cohort study of Dalbøge et al. (2014). To conclude, the present systematic review with meta-analysis contributes to knowledge of the level of exposure at which specific shoulder diseases-particularly rotator cuff lesions-should be recognized as an occupational disease.

Dose-Response Relationship between Physical Workload and Specific Shoulder Diseases-A Systematic Review with Meta-Analysis.

To determine the effectiveness of telemedicine in the delivery of diabetes care in low- and middle-income countries.
We searched seven databases up to July 2020 for randomized controlled trials investigating the effectiveness of telemedicine in the delivery of diabetes care in low- and middle-income countries. We extracted data on the study characteristics, primary end-points and effect sizes of outcomes. Using random effects analyses, we ran a series of meta-analyses for both biochemical outcomes and related patient properties.
We included 31 interventions in our meta-analysis. We observed significant standardized mean differences of -0.38 for glycated haemoglobin (95% confidence interval, CI: -0.52 to -0.23; 
Although we determined that telemedicine is effective in improving several diabetes-related outcomes, the certainty of evidence was very low due to substantial heterogeneity and risk of bias.
Mesurer l'efficacité de la télémédecine dans la prise en charge du diabète au sein des pays à faible et moyen revenu.
Nous avons examiné sept bases de données, la plus récente datant de juillet 2020, en quête d'essais cliniques randomisés s'intéressant à l'efficacité de la télémédecine dans les soins prodigués aux patients diabétiques résidant dans des pays à faible et moyen revenu. Nous y avons trouvé des informations sur les caractéristiques de l'étude, les principaux critères d'évaluation et l'ampleur des effets pour les résultats obtenus. Grâce à des modèles à effets aléatoires, nous avons mené une série de méta-analyses sur les résultats biochimiques et les propriétés des patients concernés.
Notre méta-analyse a tenu compte de 31 interventions. Nous avons observé d'importantes différences moyennes standardisées: −0,38 pour l'hémoglobine glyquée (intervalle de confiance de 95%, IC: −0,52 à −0,23; 
Bien que nous ayons établi l'efficacité de la télémédecine dans l'amélioration de nombreux résultats liés au diabète, le degré de certitude s'est révélé très bas en raison d'une grande hétérogénéité et du risque de biais.
Determinar la eficacia de la telemedicina en la prestación de servicios de atención sanitaria de la diabetes en los países con ingresos bajos y pocos medios.
Se realizaron búsquedas en siete bases de datos hasta julio de 2020 para encontrar ensayos controlados aleatorios que investigaran la eficacia de la telemedicina en la prestación de servicios de atención de la diabetes en países con ingresos bajos y pocos medios. Se extrajeron datos sobre las características del estudio, las principales variables de evaluación y los tamaños del efecto de los resultados. Utilizando el análisis de los efectos aleatorios, realizamos una serie de metaanálisis tanto para los resultados bioquímicos como para las propiedades relacionadas con los pacientes.
Incluimos 31 intervenciones en nuestro metaanálisis. Se observaron diferencias medias estandarizadas significativas de -0,38 para la hemoglobina glicosilada (intervalo de confianza del 95%, IC: -0,52 a -0,23; I
Aunque se determinó que la telemedicina es eficaz para mejorar varios resultados relacionados con la diabetes, la certeza de las pruebas fue muy baja debido a la considerable heterogeneidad y el riesgo de sesgo.
الغرض تحديد مدى فعالية العلاج الطبي عن بعد في تقديم الرعاية لمرض السكري في البلدان منخفضة الدخل والبلدان متوسطة الدخل. الطريقة قمنا بالبحث في سبع قواعد للبيانات حتى يوليو/تموز 2020، عن تجارب معشاة مضبطة بالشواهد للتحقق من فعالية العلاج الطبي عن بعد في تقديم الرعاية لمرض السكري في البلدان منخفضة الدخل والبلدان متوسطة الدخل. واستخلصنا البيانات حول خصائص الدراسة، ونقاط النهاية الأولية، وأحجام تأثير النتائج. وباستخدام تحليلات التأثيرات العشوائية، قمنا بإجراء سلسلة من التحليلات التلوية لكل من النتائج الحيوية الكيميائية، والخصائص المتعلقة بالمريض. النتائج قمنا بتضمين 31 تدخلاً في تحليلنا التلوي. لاحظنا متوسطات فروق معيارية ملموسة بقيمة -0.38 في الهيموجلوبين السكري (فاصل الثقة 95%: -0.52 إلى -0.23؛ / 
探讨远程医疗在中低收入国家糖尿病护理方面的应用效果。.
截至 2020 年 7 月，我们检索了 7 个数据库，开展随机对照试验以研究远程医疗在中低收入国家糖尿病护理方面的应用效果。我们提取了与研究特征、主要终点和结果效应值有关的数据。通过使用随机效应分析，我们针对生化结果和相关患者属性进行了一系列荟萃分析。.
我们将 31 项干预措施纳入了荟萃分析。我们观察到显著的标准化均数差，具体地，糖化血红蛋白的标准化均数差为0.38（95% 置信区间，CI：0.52 至 0.23；
虽然我们确定远程医疗可以有效地改善一些糖尿病引起的症状，但由于存在严重的异质性和偏差风险，证据确定性非常低。.
Определить эффективность телемедицины для оказания медицинской помощи при диабете в странах с низким и средним уровнем доходов.
Авторы провели поиск по семи базам данных до июля 2020 года на предмет рандомизированных контролируемых исследований, посвященных эффективности телемедицины как способа оказания помощи при диабете в странах с низким и средним уровнем доходов. Были извлечены данные о характеристиках исследования, основных конечных точках и величинах эффекта в результатах. Используя анализ случайных эффектов, авторы выполнили серию метаанализов как биохимических результатов, так и связанных с ними свойств пациентов.
В метаанализ был включен 31 случай вмешательства. Авторы наблюдали значительную стандартизованную разницу средних значений, составившую -0,38 для гликированного гемоглобина (95%-й ДИ: -0,52–-0,23; 
Хотя было выявлено, что телемедицина эффективна для улучшения некоторых результатов, связанных с диабетом, достоверность доказательств была очень низкой из-за значительной неоднородности и риска систематической ошибки.