Effects of high versus low inspiratory oxygen fraction on postoperative clinical outcomes in patients undergoing surgery under general anesthesia: A systematic review and meta-analysis of randomized controlled trials.
Published
September 15, 2021
Journal
Journal of clinical anesthesia
PICOID
f8e14846
DOI
Citations
12
Keywords
Atelectasis, General anesthesia, Inspiratory oxygen fraction, Pneumonia, Postoperative outcome
Copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Patients/Population/Participants
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Intervention
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Comparison
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Outcome
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Abstract
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To determine whether high perioperative inspired oxygen fraction (FiO Meta-analysis of randomized controlled trials. Operating room, postoperative recovery room and surgical ward. Surgical patients under general anesthesia. High perioperative FiO The primary outcome was mortality within 30 days. Secondary outcomes were pulmonary outcomes (atelectasis, pneumonia, respiratory failure, postoperative pulmonary complications [PPCs], and postoperative oxygen parameters), intensive care unit (ICU) admissions, and length of hospital stay. A subgroup analysis was performed to explore the treatment effect by body mass index (BMI). Twenty-six trials with a total 4991 patients were studied. The mortality in the high FiO The use of high FiO