Comparison of glomerular filtration rate estimating equations in older adults: A systematic review and meta-analysis.

Abstract

Debates persist regarding the performance of existing glomerular filtration rate (GFR) estimating equations in older individuals. We performed this meta-analysis to assess the accuracy and bias of six commonly used equations, including the Chronic Kidney Disease Epidemiology Collaboration creatinine equation (CKD-EPI PubMed and the Cochrane Library were searched for studies comparing estimated GFR (eGFR) with measured GFR (mGFR). We analyzed the difference in P30 and bias among the six equations and investigated subgroups based on the area (Asian and non-Asian), mean age (60-74 years and ≥75 years), and levels of mean mGFR (<45 mL/min/1.73m 27 studies with 18,112 participants were included, all reporting P30 and bias. BIS1 and FAS Overall, BIS and FAS provided relatively more accurate estimates of GFR than CKD-EPI in older adults. FAS

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