The OXTR polymorphisms are not associated with attachment dimensions: A three-approach study.

Published
July 08, 2020
Journal
Psychoneuroendocrinology
PICOID
e49778f1
DOI
Citations
8
Keywords
Attachment dimension, Cross-sectional analysis, Meta-analysis, Oxytocin receptor gene, Three-wave analysis
Copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Patients/Population/Participants

college students, freshmen

Intervention

three studies: (1) cross-sectional study, (2) three-wave study, (3) meta-analysis

Comparison

OXTR polymorphisms (rs53576 and rs2254298), attachment dimensions

Outcome

not significantly associated, not associated, not related

Abstract

P
I
C
O

Inspired by the roles of oxytocin in social behaviors, scientists have devoted considerable efforts to examine the association between the oxytocin receptor gene (OXTR) and human attachment, a personality of seek and receiving comfort from intimate figures. However, there are still a lot of controversies on the association. To clarify the relationship, this research integrated three studies: (1) A cross-sectional study indicated that the OXTR polymorphisms (i.e., rs53576 and rs2254298) were not significantly associated with attachment dimensions in a college student sample (N = 1193); (2) A three-wave study showed that the polymorphisms were not associated with the individual differences and changes of attachment dimensions in a freshmen sample (N = 657); and (3) Meta-analysis indicated that attachment dimensions were not associated with the polymorphisms of rs53576 (Anxiety: 14 samples, N = 5053; Avoidance: ten samples, N = 4273) and rs2254298 (Anxiety: ten samples, N = 3670; Avoidance: ten samples, N = 3698). Taken together, these findings provide strong evidence that the OXTR polymorphisms are not related to attachment dimensions.

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