A stop-gain variant in
Published
November 08, 2022
Journal
HGG advances
PICOID
da52b21f
DOI
Citations
1
Keywords
Polynesia, cardiovascular disease risk factors, genetics of complex traits, identification of disease genes, isolated population
Copyright
© 2022 The Authors.
Patients/Population/Participants
Micronesian, Polynesian
Intervention
association study
Comparison
HDL-C
Outcome
R218∗
Abstract
P
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C
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Current understanding of lipid genetics has come mainly from studies in European-ancestry populations; limited effort has focused on Polynesian populations, whose unique population history and high prevalence of dyslipidemia may provide insight into the biological foundations of variation in lipid levels. Here, we performed an association study to fine map a suggestive association on 5q35 with high-density lipoprotein cholesterol (HDL-C) seen in Micronesian and Polynesian populations. Fine-mapping analyses in a cohort of 2,851 Samoan adults highlighted an association between a stop-gain variant (rs200884524; c.652C>T, p.R218∗; posterior probability = 0.9987) in