Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas.
Published
January 08, 2024
Journal
Cell genomics
PICOID
b74b8ddf
DOI
Citations
0
Keywords
admixed populations, chronic kidney disease, eGFR, expression quantitative trait locus, fine-mapping, genome-wide association study, kidney function, multi-ancestry, polygenic scores
Copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Patients/Population/Participants
African ancestry, individuals of African ancestry
Intervention
genome-wide association studies
Comparison
no GWASs
Outcome
identified 41 loci at genome-wise significance
Abstract
P
I
C
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Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta-analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p < 5 × 10