Association between
ASD cases, controls
rs16976358 polymorphism
C vs. T
risk for ASD
Abstract
Recent studies have shown that Ras-like without CAAX2 ( We searched literature from the databases PubMed, Embase, Google Scholar, ScienceDirect, EBSCOhost, OVID, Web of Science, and Wiley up to February 2021. Three studies including 1160 ASD cases and 1367 controls were eventually enrolled in the meta-analysis based on strict inclusion and exclusion criteria. All genetics models indicate a significant association between rs16976358 polymorphism and ASD susceptibility (C vs. T: Our meta-analysis exhibits that the allele C, CC, and CT genotyping of rs16976358 suggest the risk for ASD, but additional studies using a large sample size and ethnically diverse populations need to be included in the future.