Perinatal outcomes after vitrified-warmed day 5 blastocyst transfers compared to vitrified-warmed day 6 blastocyst transfers: A meta analysis.

Abstract

The aim of this meta-analysis was to compare the perinatal outcomes between the vitrified-warmed day 5 blastocyst transfer (BT) and the vitrified-warmed day 6 blastocyst transfer (BT). PubMed, EMBASE and the Cochrane Library were searched for the perinatal outcomes after in vitro fertilisation / intracytoplasmic sperm injection (IVF/ICSI) from inception to October 2018.The perinatal outcomes included birth weight, gestational age, number of males, premature delivery, birth defects, and neonatal deaths. We used a random effect model to analyse the summary risk ratios (RRs) and mean difference (WMD) with 95 % confidence intervals (CIs). Eight retrospective studies that met the inclusion criteria were included. Compared with vitrified-warmed day 5 BT, vitrified-warmed day 6 BT was associated with increased birth weight (WMD = -80.39; 95 % CI = -151.8 to -8.97; I Vitrified-warmed day 6 BT is associated with increased birth weight rather than day 5 BT. There was no difference in gestational age, number of males, premature deliveries, birth defects, and neonatal death, between the two groups. These results concluded that vitrified-warmed day 6 BT has no difference compared with vitrified-warmed day 5 BT in regard to adverse impact on perinatal outcomes.

Similar article map