Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach.
Published
December 25, 2021
Journal
Genes
PICOID
a1cce929
DOI
Citations
5
Keywords
SERPINE1, diabetic nephropathy, gene polymorphism, meta-analysis, systematic review
Copyright
Patients/Population/Participants
patients with DN, T2DM patients without DN, healthy controls
Intervention
selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap
Comparison
present association study regarding
Outcome
strong evidence that
Abstract
P
I
C
O
Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is A total of 190 patients with DN, 150 T2DM (type 2 diabetes mellitus) patients without DN and 238 healthy controls were recruited. We selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap. The generalized odds ratio (OR Both the present association study regarding In conclusion, the present association study and meta-analysis provides strong evidence that