Serine and arginine rich splicing factor 1 deficiency alters pathways involved in IL-17A expression and is implicated in human psoriasis.
Published
May 26, 2022
Journal
Clinical immunology (Orlando, Fla.)
PICOID
9f524f5c
DOI
Citations
3
Keywords
Alternative splicing, Autoimmunity, Il-17, Psoriasis, SRSF1
Copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Patients/Population/Participants
SRSF1, lymphocytes
Intervention
conditional deletion
Comparison
wild type
Outcome
increased expression of IL-17A and IL-17F
Abstract
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C
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Serine and Arginine Rich Splicing Factor 1 (SRSF1) is a splicing factor that binds to exonic enhancers and stimulates splicing and is previously implicated with autoimmunity. Herein, we investigate the role of SRSF1 in regulating innate immune functions that are pertinent in the pathogenesis of auto-inflammatory diseases. Specifically, we show that conditional deletion of SRSF1 in mature lymphocytes resulted in higher expression of il-17a and il-17 f and an expansion of IL17A