Antiphospholipid Antibodies and Autoimmune Haemolytic Anaemia: A Systematic Review and Meta-Analysis.
adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) patients
EMBASE/PubMed search and meta-analysis using Peto's odds ratios
AIHA +ve vs. AIHA -ve patients
pooled prevalence (PP) of IgG/IgM anticardiolipin (aCL) and lupus anticoagulant (LA)
Abstract
The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/PubMed search from inception to June 2019 and meta-analysis using Peto's odds ratios. The pooled prevalence (PP) of IgG/IgM anticardiolipin (aCL) and lupus anticoagulant (LA) was greater in AIHA +ve than AIHA -ve patients (34.7% vs. 27.6%,