Ferulic Acid in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies.
Published
October 24, 2021
Journal
Cells
PICOID
8b7fc2fa
DOI
Citations
21
Keywords
Alzheimer’s disease, animal models, ferulic acid, systematic review
Copyright
Patients/Population/Participants
animals
Intervention
ferulic acid (FA)
Comparison
pre-clinical researches
Outcome
neuroprotective effects in AD models
Abstract
P
I
C
O
Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence in the elderly. Many preclinical studies show that a natural product, ferulic acid (FA), displays neuroprotective effects in AD models. This review aims to systematically review and meta-analyze published pre-clinical researches about the effects, mechanism, and clinical prospects of FA in the treatment of AD. According to the pre-determined search strategy and inclusion criteria, a total of 344 animals in 12 papers were included in the meta-analysis. We used the fixed effects model to analyze data and I