A Signature-Based Classification of Gastric Cancer That Stratifies Tumor Immunity and Predicts Responses to PD-1 Inhibitors.
Published
June 29, 2021
Journal
Frontiers in immunology
PICOID
82b77479
DOI
Citations
9
Keywords
anti-tumor immunity, gastric cancer, immune checkpoint inhibitors, molecular classification, tumor biomarkers
Copyright
Copyright © 2021 Li, Gao, Xu, Zhang, Huang, Dai, Huang and Liu.
Patients/Population/Participants
patients with gastric cancer
Intervention
immunotherapy
Comparison
-
Outcome
prognosis prediction, individualized treatment
Abstract
P
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Gastric cancer is a leading cause of cancer-related deaths with considerable heterogeneity among patients. Appropriate classifications are essential for prognosis prediction and individualized treatment. Although immunotherapy showed potential efficacy in a portion of patients with gastric cancer, few studies have tried to classify gastric cancer specifically based on immune signatures. In this study, we established a 3-subtype cluster with low (C