Split hand in amyotrophic lateral sclerosis: A systematic review and meta-analysis.
patients with amyotrophic lateral sclerosis (ALS)
systematic search of PubMed, EMBASE, OVID and other databases
split hand syndrome
frequency of split hand sign in ALS patients
Abstract
To investigate the frequency of split hand (SI) and its diagnostic performance in amyotrophic lateral sclerosis (ALS). PubMed, EMBASE, OVID and other databases were searched systematically up to March 2021 for relevant reports about the split hand syndrome. Two reviewers screened and selected the titles and abstracts of the studies independently during the database searches and performed full-text reviews and extracted available data. In our study, AA Pooled results of five studies including 339 patients showed that 50% (95%CI: 35%-65%) of patients with ALS presented split hand. APB/ADM Half of ALS patients might show split hand sign. SI