Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-Analysis.

Published
April 11, 2020
Journal
International journal of environmental research and public health
PICOID
7df65d9f
DOI
Citations
49
Keywords
arsenic, cardiovascular disease, dose-response, low level, meta-analysis, systematic review
Copyright
Patients/Population/Participants

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Intervention

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Comparison

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Outcome

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Abstract

P
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To the best of our knowledge, a dose-response meta-analysis of the relationship between cardiovascular disease (CVD) and arsenic (As) exposure at drinking water As concentrations lower than the WHO provisional guideline value (10 µg/L) has not been published yet. We conducted a systematic review and meta-analyses to estimate the pooled association between the relative risk of each CVD endpoint and low-level As concentration in drinking water both linearly and non-linearly using a random effects dose-response model. In this study, a significant positive association was found between the risks of most CVD outcomes and drinking water As concentration for both linear and non-linear models (

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