Autologous platelet-rich plasma treatment for patients with diabetic foot ulcers: a meta-analysis of randomized studies.
patients with diabetic foot ulcers (DFU)
autologous PRP
standard treatment or placebo
complete ulcer healing rate, time to healing, adverse events
Abstract
This study will explore the effectiveness and safety of autologous PRP in the treatment of patients with DFU. The electronic databases of PubMed, EMBASE, BIOSIS, Cochrane central, and Google Scholar internet were searched updated on Jan 30, 2020. Evaluated outcomes included rate of complete ulcer healing, time to healing and adverse events. Statistical analysis was performed with RevMan 5.0 software and STATA 10.0 software. Ten RCTs with 456 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (RR = 1.32, 95% CI 1.06 to 1.65, P = 0.01, I Our findings suggest that autologous PRP may improve the complete ulcer healing rate, shorten the healing time, with no increasing the incidence of adverse events.